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KMID : 0892920190280010043
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Experimental Neurobiology
2019 Volume.28 No. 1 p.43 ~ p.53
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14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors
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Kim Do-Eon
Cho Chang-Hoon
Sim Kyoung-Mi
Kwon O-Sung
Hwang Eun-Mi
Kim Hyung-Wook
Park Jae-Yong
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Abstract
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14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.
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KEYWORD
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14-3-3γ, Ywhag, Hyperactivity, Anxiety, Acute stress, ADHD
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